Important Facts About: Etizolam

Important Facts About: Etizolam

Etizolam is a drug belonging to the thienodiazepine class. It is commonly used to treat insomnia, anxiety or panic attacks. It is a benzodiazepine analog. It’s system name is 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. It has anxiolytic, amnesic, anticonvulsant, sedative, hypnotic and muscle relaxant properties. Although scheduled in some countries, it is readily available and can be purchased online in several websites like and It is commonly sold as Etizolam, “Etilaam”, “Etizest”.


There aren’t many sources narrating the history of etizolam as a medicinal drug. However, its use as a drug for anxiety treatment dates back as early as the 1990s, as documented in several research papers.
The substance rose to popularity in 2011 as a research drug and substitute for benzodiazepine.


Etizolam usually comes in a tablet or pellet form. However, it can also be purchased as a powder. In the website, it is sold in tablet form in 0.5 and 1 mg. The threshold for it is at 0.2 to 0.5 mg. Light dosage is pegged at 0.5 -1 mg. Common dosage is one (1) to two (2) mg. Strong dosage is two (2) to five (5) mg. While on the other hand, heavy dosage is five (5) mg and above. It is advisable to first get a prescription from a physician before taking the drugs.
It is usually taken orally or sublingually. However, some reports have shown that it can also be injected and taken anally. These methods, however, are not yet scientifically proven. It should be taken with food, at least 15 to 30 minutes after meals.


The effects of Etizolam can be usually felt after thirty (30) minutes to one (1) hour. These effects often last six (6) to eight (8) hours. The peak of the effects is after two (2) to three (3) hours. After effects can last as long as six (6) hours to a day. The following are some of the effects of Etizolam:
The following are the physical effects of etizolam:

1. Sedation – Etizolam is a rapid-acting sedative. For those who took high doses, they may feel exhausted and sleep deprived instantly. At very large doses, it can even cause complete unconsciousness. It must therefore be taken at the right amount.
2. Motor control loss and muscle relaxation – Muscle relaxation is one of the side effects of the sedative abilities of this drug.
4. Physical euphoria – this side effect is one of the reasons why a lot of people become addicted to etizolam.
5. Appetite enhancement
6. Suppress seizure – the drug suppresses seizures as a result of its muscle relaxant effect and sedation.
7. Increased libido
8. Temporary erectile dysfunction
9. Dizziness
10. Stomach discomfort and pain

Etizolam also has known paradoxical effects. These are the effects that are different or opposite from what is normally expected. These effects often happen rarely. But abusers, dependents, children, patients with mental disorders have a higher probability of experiencing them. The following are some of the paradoxical effects of etizolam: increased seizures especially for epileptics, aggression, increased anxiety, irritability, loss of impulse control, excessive salivation, violent behavior, slurred speech, urinary retention, urinary incontinence, visual disturbances and slurred speech.

Just like any drug, etizolam also has a lot of cognitive effects. The following are some:

1. Disinhibition
2. Anxiety suppression
3. Cognitive euphoria
4. Compulsive redosing
5. Memory Suppression or Amnesia
6. Thought deceleration
7. Motivation Suppression
8. Ego inflation
9. Emotionality suppression
10. Delusions of sobriety

It has also been found to cause rebound anxiety, residual sleepiness, dream suppression, and thought disorganization even after a few weeks from the intake.
Tolerance, dependence, and withdrawal

Due to its chemical make-up, Etizolam can cause dependence. Like benzodiazepines, rapid or abrupt discontinuation from it may cause benzodiazepine withdrawal syndrome. The symptoms of this syndrome include rebound insomnia and neuroleptic malignant syndrome.

In a study comparing the effectivity of alprazolam, bromazepam and etizolam in treating generalized anxiety disorder, it was found that etizolam was more effective from the two (2) weeks to four (4) weeks period, as this was a form of reverse tolerance. A half milligram of etizolam administered twice daily over the span of three weeks did not induce cognitive deficits as compared to placebo.

In a separate study using rat neurons, it was found that etizolam reduced liability to induce dependence and tolerance as compared to other types of benzodiazepines.


Etizolam has adverse when taken with alcohol. Simultaneous or successive intake of alcohol and etizolam may cause drowsiness, blood pressure drop, nervous system depression, impairment of thoughts and impairment of perception.
It should also not be taken with any depressants, dissociatives, and stimulants. Particularly, it should not be taken with Antifungals, Cetirizine, Cimetidine, Cisapride, Clonidine, Clozapine, Diazoxide, Disulfiram, Diuretics, Dopaminergic, Esomeprazole, Hydralazine, Lofexidine, Minoxidil, Morphine, Moxonidine, Muscle relaxants, Nabitone, Nitrates, Nitroprusside, and Omeprazole.

People suffering from conditions such as pulmonary insufficiency, liver disease, and glaucoma should also avoid using it. Pregnant and breastfeeding women should also not take the drugs. Furthermore, it is contraindicated for patients suffering from a coma, sleep apnoea, myasthenia gravis, chronic psychiatric illness, hypotension, porphyria, impaired renal clearance disorders and those with suicidal thoughts.

Legal Status

As mentioned earlier in the article, Etizolam is scheduled in some countries. There are also countries like India that allow the use of it. In Japan, it is called Depas. It has been restricted and classified as a benzodiazepine analog since October 2016. The same is the situation in Germany and Denmark. In Denmark, the government issued a law entitled Danish Misuse of Drugs Act to control the sale, distribution, and use of said drugs and other like products. In the United Kingdom, it is classified as a class C drug according to the Misuse of Drugs Act 1971. The United States Food and Drugs Administration does not authorize the medical use of the drug. The drug is considered as a controlled substance in several states like Alabama, Arkansas, Georgia, Florida, Indiana, Louisiana, Mississippi, and Virginia.

In countries with no prohibition against it, it is readily available online. As aforementioned it can be bought on websites like and