What You Need to Know About: Etizolam

What You Need to Know About: Etizolam

Etizolam is one of the many drugs used as a medication for depression. It is fast-acting and belongs to the thinodiazepine chemical class. It suppresses anxiety, disinhibits and relaxes the muscles and suppresses the memory. It is usually administered either orally or sublingually. Etizolam is usually sold in tablet form. However, it can also be purchased in a pellet form.

Legal Status

Etizolam is not classified as a controlled substance in a lot of countries. Some even do not prescribe its use. However, because of this, it is a favorite research substitute for drugs under the benzodiazepine family. In Japan, it is called Depas. However, it has been restricted as a benzodiazepine analog since October 2016. On the other hand, in Germany, it’s distribution has been controlled since July 13. Meanwhile, the Danish government issued the Danish Misuse of Drugs Act to control the use, distribution, and sale of etizolam and like substances. The United Kingdom classified it as a class C drug as of May 2017 pursuant to their Misuse of Drugs Act 1971. In the United States, the Food and Drugs Administration has not authorized the drug for medical use. However, the drug is considered as a controlled substance in several states namely Arkansas, Alabama, Mississippi, Florida, Texas, Georgia, Virginia, Indiana, and Louisiana.In countries that authorize its use, it is commonly sold under the brand names, Etilaam and Etizest. It is also sold on the internet on several websites such as www.tramadolshop.is and etizolamshoponline.com.


It was first used as a research chemical back in 2011. Because of its abundance and low production cost, it rose to popularity. Its roots as a medical drug are not well-documented. However, there are medical papers dating back in the 1990s citing it as a treatment for anxiety.


The effect of this substance usually kicks in about thirty (30) to sixty (60) minutes after the initial intake. The effects usually last for an average of six (6) to eight (8) hours. The effects are at peak at around two (2) to four (4) hours after initial intake. The effects can last up to a day depending on how large the dose is. This section will be divided into three parts; identifying the physical effects, paradoxical effects, and cognitive effects.

The following are the physical effects of etizolam:

1. Sedation – Etizolam is a rapid-acting sedative. For those who took large doses, they may feel exhausted and sleep deprived instantly. At very large doses, it can even cause complete unconsciousness. It must, therefore, be taken at the right amount.
2. Muscle relaxation – Muscle relaxation is one of the side effects of the sedative abilities of this drug.
3. Motor control loss
4. Physical euphoria – this side effect is one of the many reasons why this substance is considered addictive.
5. Increased Libido
6. Suppress seizure – the drug suppresses seizures as a result of its muscle relaxant effect and sedation.
7. Appetite enhancement
8. Temporary erectile dysfunction
9. Dizziness
10. Stomach discomfort and pain
11. Reduces schizophrenic delusions – Etizolam reduces auditory delusion which is a symptom of schizophrenia.
12. Prevents brain disorders – Etizolam has been observed to reduce the symptoms of neuroleptic malignant syndrome. This sickness is characterized by unstable blood pressure levels, muscular dysfunction and high fever. Aside from that,

it was also shown to have the ability to reduce chronic subdural hematoma. Such condition takes place when blood pools around the brain.

Aside from the aforementioned effects, Etizolam may also produce paradoxical effects. Such effects are those that are different or opposite from what would normally be expected. The following are some of the paradoxical effects of etizolam:

1. Increased seizures especially for epileptics
2. Increased anxiety
3. Aggression
4. Loss of impulse control
5. Irritability
6. Violent Behavior
7. Excessive Salivation
8. Urinary retention and/or urinary incontinence
9. Slurred speech
10. Visual disturbances

It is important to note that the aforementioned paradoxical effects seldom happen. However, abusers, dependents, individuals with mental disorders, patients on high-dosage and children have a higher probability of experiencing the aforementioned side effects.

Like most drugs, etizolam also has a lot of cognitive effects. Here are some examples:

1. Disinhibition
2. Anxiety suppression
3. Cognitive euphoria
4. Compulsive redosing
5. Memory Suppression or Amnesia
6. Thought deceleration
7. Motivation Suppression
8. Ego inflation
9. Emotionality suppression
10. Delusions of sobriety

After its effects wear off, the user may experience a myriad of after-effects such as rebound anxiety, dream suppression, residual sleepiness, though disorganization and deceleration.


Etizolam is a habit-forming drug. In a recent study, it was found that users will most likely develop sedative-hypnotic effects upon continued use. Upon cessation, tolerance level for the drug will return to normal in a week or two. Withdrawal and rebound symptoms, however, can occur after abrupt cessation of intake. It is therefore advised that the withdrawal is done in a gradual manner. Like most drugs, etizolam should not be taken with alcohol. The use of alcohol and etizolam simultaneously or successively may cause nervous system depression, drowsiness, blood pressure drop, impairment of perception and impairment of thoughts.

As a general rule, it should not be used with any depressants, stimulants, and dissociatives. The following are the medications etizolam cannot be taken with: Antifungals, Cetirizine, Cimetidine, Cisapride, Clonidine, Clozapine, Diazoxide, Disulfiram, Diuretics, Dopaminergics, Esomeprazole, Hydralazine, Lofexidine, Minoxidil, Morphine, Moxonidine, muscle relaxants, Nabitone, Nitrates, Nitroprusside, and Omeprazole.

People with pre-existing conditions like glaucoma, pulmonary insufficiency, and liver disease should also avoid using the said drug. Women who are pregnant and breastfeeding should also avoid using etizolam. Additionally, individuals with the following diseases should also not take it: coma, sleep apnoea, mysasthenia gravis, chronic psychiatric illness, hypotension, porphyria, impaired renal clearance disorders and those with suicidal thoughts. Etizolam is a drug used to treat disorders like anxiety and insomnia. Unlike its other counterparts, it has lesser side effects and is less addicting. However, it should still be used with precaution. This article briefly discussed the history, advantages and side effects on said drug. It is readily available on the internet especially on websites like www.tramoda.is