Etilaam 0.5mg Tablet
Intas Pharmaceuticals Ltd
Etizolam is an anti-anxiety medicine chemically-related to the class of medicines called benzodiazepines. It is known for trade names such as Etilaam, Etizola, Etizest, Pasaden, Depas, and Sedekopan.
Just like benzodiazepines, Etizolam is used for the treatment of anxiety and insomnia among other uses. The common administration is orally and sublingually, which are found to be the most efficient routes.
Properties, Appearance, and Composition
As mentioned before, Etizolam is similar to benzodiazepine medicines. Thus they also have parallel composition and effects. This medicine’s active ingredient is Etizolam with the chemical composition of:
The difference between benzodiazepine and Etizolam is the latter has thiophene ring bonded to a seven-membered 1, 4-diazepine ring instead of a benzene ring.
It also contains a bonded triazolo ring and a 2-chlorophenyl ring attached to the 4-position. On the other hand, in its thienodiazepine ring structure is an ethyl group attached to the 2-position.
The molecular formula of the Etizolam is C17H15ClN4S while its molecular weight is 342.8 grams per molecule. Upon consumption, the liver metabolizes the substance and excretes it through the kidneys.
An average Etizolam has a half-life of six hours with 93 percent bioavailability. The most common form of Etizolam is the pill – small, blue, and round with a line down its middle. It’s also available in powder or liquid.
As an antidepressant, sedative-hypnotic, and anxiolytic medication, Etizolam is commonly used by adults as an oral therapeutic medicine. It is used for the treatment of medical conditions such as anxiety, stress, and convulsions.
Sometimes, it is also used to treat a slight form of insomnia as it has a great relaxing effect on the mind thereby inducing sleep. Etizolam has also found use in the management of situational, psychological disorders like panic attacks.
Aside from sleeping disorders and depression, Etizolam has also been noted to relieve, control, and manage
- Tension headaches
- Lower back pains
- Cervical spine disorders
- Seizure disorders
The ideal dosage for taking Etizolam is as per the doctor’s advice but the standard dosage is 1 to 2 mg. This is taken either orally or sublingually, meaning under the tongue to be absorbed by the body.
On the other hand, Etizolam’s dosage can differ based on what the user will be taking the medicine for, whether it’s anxiety, insomnia, or panic attack. Physicians also prescribe them based on the patient’s health status.
- Anxiety: 25 to 0.5g/twice daily for anxiety and stress.
- Insomnia: 1 to 2mg/daily for insomnia and sleep regulation.
- Panic Disorder: 5mg/twice daily for panic attacks and related disorders.
The maximum dosage for Etizolam is 3mg, which should not be exceeded. Currently, it is available in 0.25 mg, 0.5 mg, and 1.0 mg tablets. The user can use any Etizolam strength as required.
What if I miss a dose?
If a user missed a dose, it’s advised to take it as soon as remembered. However, if it is almost the time for next dose then it is okay to skip the missed one to avoid overdosing.
As much as possible, the user should try not to miss any dose. This is because Etizolam’s quantity and timing are precise. If the user does not adhere to them, it can result in several additional side effects.
What to do in case of an overdose?
Any incidence of overdose must be reported to the doctor as soon as possible. This is critical since the symptoms are usually fatal, especially if Etizolam is consumed by a child or someone without a prescription.
The symptoms of Etizolam overdose may include decreased rate of heartbeat, a slower rate of breathing, fainting, and severe drowsiness. These symptoms can be severe and must be handled immediately.
How Long Before Etizolam Takes Effect?
Etizolam is a thienodiazepine derivative, therefore its faster absorption system. As a hypotonic compound, it follows the mechanism of action where it attaches to the benzodiazepine receptor.
Its best effects manifest 25 to 30 minutes after taking the dose. The wait time before the medicine takes effect can take up to a couple of hours. If the two hours is up and the user is not seeing results, they may need to take another or increase the dose.
Compared to similar compounds, Etizolam is safer and poses little accumulation risk even with long-term use. Etizolam effectively acts as a full agonist, which ensures that it offers the best relaxing benefits.
Duration of Effects
Taking this medicine provides therapeutic benefits that can last for an average duration of 6 to 8 hours. This effect can also be further extended if the user has long, uninterrupted sleep after consuming the medicine.
What Are the Effects of Etizolam?
When taken, it’s said that the user experiences some feelings of euphoria and a relaxing effect. Users of this medicine often describe the effects to be a general sense of relaxation and well-being.
It’s reported by many of its users that Etizolam makes it easier for them to fall asleep. In addition, there are other effects such as muscle relaxation, increased appetite, and anxiety suppression.
Here is a list of the other known effects of Etizolam:
- Loss of motor control
- Muscle relaxation
- Respiratory depression
- Enhanced appetite
- Increase libido
- Suppressed seizures
- Ego inflation
How Does Etizolam Work?
Etizolam’s therapeutic effects work through the inhibitory GABA neurotransmission. This is one of the things that differentiate Etizolam and benzodiazepine medicines, as it makes the former somewhat more accurate.
Furthermore, Etizolam’s affinity for binding to the postsynaptic GABA receptor subtype’s A2 unit is a lot higher. Because of this higher affinity and thus activation, Etizolam produces an amazing relaxing effect.
How Do You Take Etizolam?
This medicine is over-the-counter but obtaining a prescription dose from a doctor for the correct dosage would be safer. A doctor can give advice on the most useful treatment by age, weight, health condition, and requirement.
Following the instructions of the doctor, it is likely the dose will be modified along the way of the treatment. All the changes as instructed by the doctor must be properly followed to ensure the maximum benefits of the medicine.
If the user does not, he or she will likely experience certain side effects. Eventually, usage of the medicine is stopped as per the doctor’s instruction and guidance, which avoids withdrawal symptoms.
Short and Long-Term Use
Doctors typically prescribe this medicine for 12 weeks maximum. To obtain the most benefits in using Etizolam, the user must strictly consume the prescribed dosage regularly.
If the user leaves consumption of the medicine halfway, it could result in disruption of its benefits. This is the reason why it’s not recommended to stop taking the medicine at once.
The correct way is to reduce the dosage slowly to lessen the risk of unwanted effects. In case of a missed dose, the user must follow the instructions mentioned above to avoid experiencing an overdosing effect.
If taken in reasonable dosage and strict recommendation of the doctor, there should not be any long-term negative effects or issues with using Etizolam.
If not used properly, a person may experience long-term side effects such as loss of sex drive, but not everyone experiences them. Most people are not affected but it is important to know the possibilities of Etizolam misuse.
Instructions for Storage
Etizolam’s chemical composition makes it safe to store at room temperature, which is between 20 and 25-degree Celsius. Its general storage precautions include protection from direct sunlight, heat, and moisture.
If stored under these conditions, the compound’s chemical structure may change. Before purchase, it’s important to check the expiry date that is usually printed on the medicine’s original packing.
Consumption of Etizolam is not safe for children, underage people, as well as people suffering from certain medical conditions. If there are leftover tablets, follow the proper disposal method for safety.
Etizolam Safe Usage
Like all medicines, Etizolam also has limitations for safe usage. It especially requires caution in dosage design. With this medication, the least dosage is the better.
This is why Etizolam is available in smaller strength only. Even though it is not regulated and easily bought over the counter, following safety measures is crucial whether in small or large applications.
Etizolam is only effective when taken in the right amount. It is not helpful to the user to take lower or higher dose. With a lower dose, the desired effects are not attained while higher dose results to uncomfortable effects.
When Not To Use
The safe use of Etizolam includes studying the health history and understanding of the current health status of the user. Before writing a prescription, the doctor must know if you have the following contraindications of Etizolam:
- Myasthenia gravis – Etizolam is not recommended for use by anyone with muscles that tire easily, thus causing complications such as severe weakness.
- Porphyria – Anyone with porphyria, a rare blood disease, is not recommended to take this medicine.
- Narrow-angle glaucoma – People suffering from narrow-angle glaucoma is not recommended to take Etizolam.
- Etizolam allergy – It is not recommended to take Etizolam if a person has a known history of allergy to this product or its ingredients.
In addition to these conditions, Etizolam is also not recommended for use if one has:
- Respiratory depression
- Pulmonary insufficiency
- Sleep apnea
- Liver dysfunction
- Phobic states
- Chronic psychosis
Frequently Asked Questions
Here are a few questions that concern the use of Etizolam:
Is it safe to use with alcohol?
Etizolam is not safe to use with alcohol so it’s best to avoid drinking. Similarly, don’t perform physical activities that require mental alertness when taking Etizolam. When undesired effects are experienced, contact the doctor immediately.
Is it safe to use during pregnancy or while breastfeeding?
Etizolam is not recommended for use by pregnant or breastfeeding women. If there is a need for similar medicines, a safer alternative will be prescribed by the doctor after assessment of the women’s condition.
Is Etizolam habit forming?
Etizolam has a moderate habit-forming potential. This is why it’s important to take only the recommended safe dosage as per the doctor’s instructions. Additionally, reducing the medicine must be gradual, as mentioned before.
Drugs have different interactions with every person. A user must always check all of the drug’s possible interactions before taking it.
Taking Etizolam with the following medicines can cause moderate to severe side effects:
As stated before, don’t use Etizolam with alcohol as it can result in severe nervous system depression. This can lead to a drop in blood pressure, excessive drowsiness, loss of perception, and impaired thoughts.
The user must avoid consuming grapefruit juice when taking Etizolam.
Here are Etizolam’s interactions with certain diseases:
- Liver Disease – Patients with impaired normal liver function must be cautious in using this medicine. It is recommended to take proper appropriate adjustments of the dose as well as checking of liver enzyme levels.
- Pulmonary Insufficiency – Patients with pulmonary insufficiency must take extreme caution when taking this medication. Use of this medicine if you have pulmonary insufficiency leads to high-risk breathing complications.
- Glaucoma – Extreme caution is necessary when using this medicine with people suffering from glaucoma. Tests must be performed to determine if the person has narrow-angle glaucoma before treatment with Etizolam.
In addition, extreme caution must be exercised when taking Etizolam for the following conditions:
- History of recreational drug or alcohol abuse
- Abnormal blood pressure
- Mental problems such as phobias and depression
- Activities requiring high-level mental alertness
- Personality disorder
- Elderly and bedridden patients
Etizolam is legal and currently a prescribed medicine in India, Japan, and Italy. It is a licensed medicine for the treatment of insomnia, anxiety, and neurosis in Italy, but only as prescription medication. On the other hand, Etizolam has been a benzodiazepine analog in Japan since 2016.
As mentioned throughout this article, Etizolam can cause sleepiness and must be taken as per the doctor’s instructions. Depending on your doctor’s advice, you can take this medicine with or without food.