hab Pharmaceuticals Ltd
All About Modafinil
Modafinil is a drug that promotes wakefulness. In 1998, the Food and Drug Administration, a federal agency of the U.S. Department of Health and Human Services, approved the use of Modafinil for treating narcolepsy, a condition characterized by an uncontrollable desire to sleep. It is also used to treat sleeping problems and sleep apnea, a medical disorder wherein a person experiences periods of shallow breathing during sleep.
How Modafinil Works
In general, it is a wakefulness-promoting drug utilized for treating various kinds of somnipathy such as idiopathic hypersomnia, Excessive Daytime Sleepiness (EDS), associated with the most common type of sleep apnea, ODS, and Shift Work Sleep Disorder (SWSD).
Modafinil serves as a selective and weak Dopamine Reuptake Inhibitor (DRI), a type of drug that inhibits the reuptake of both norepinephrine and dopamine. DRIs increase dopaminergic neurotransmissions as well as increase extracellular concentrations of Dopamine.
Dopamine is a neurotransmitter, a substance released by nerve cells to send brain signals to other neurons. It plays a vital role in increasing productivity, focus, and motivation since it is a major component of the execution of incentive salience, a cognition that bestows a want or a desirable attribute. Low dopamine levels in the body can lead to fatigue, memory loss, mood swings, and lack of motivation.
Moreover, the norepinephrine, a hormone that serves as a neurotransmitter, exerts powerful effects on several brain areas such as the sympathetic ganglia and other brain regions that regulate sleep, attention, and learning. Its general function is to mobilize the body and the brain for action.
Moderate to high levels of dopamine and norepinephrine significantly increases electrical activity in the brain. This can improve memory, wakefulness, and thinking skills. Truckers, college students, and call center agents utilize modafinil for off-label uses to increase productivity and to repel drowsiness. Physicians also prescribe this drug for numerous other medical conditions such as Attention Deficit Hyperactivity Disorder (ADHD), multiple sclerosis, and depression.
Modafinil raises levels of nervous activity in the body. Without producing the euphoria and addiction of amphetamines and without experiencing jitters that caffeine can bring, modafinil stimulates the brain. It is being sold under the brand name Provigil.
As stated earlier, Provigil is a wakefulness-promoting drug. It is used orally. Modafinil is a racemate, a racemic compound, and C15H15NO2S is its molecular formula.
Physically, modafinil is an off-white or a white crystalline powder. It is insoluble in cyclohexane and water; it is slightly or sparingly soluble in acetone and methanol.
A Provigil tablet contains either 200mg or 100 mg of modafinil and other inactive ingredients such as lactose monohydrate, croscarmellose sodium, povidone, magnesium stearate, pregelatinized starch, and microcrystalline cellulose.
Generally, this drug reduces extreme drowsiness due to sleep disorders such as narcolepsy and obstructive sleep apnea. It is utilized to help an individual stay awake during graveyard shifts.
Modafinil is also a eugeroic, an agent that causes arousal and good wakefulness, utilized for treating various sleep disorders and EDS, a condition characterized by lack of energy and persistent sleepiness during the daytime.
When it comes to its occupational use, the armed forces of several countries have utilized modafinil as a substitute to amphetamine. This drug is traditionally employed in lengthy missions and in combat situations where soldiers face food and sleep deprivation.
The Foreign Legion utilized the drug in some covert operations. The Indian Air Force proclaimed that they included it in their contingency plans.